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Fibroblast Activity and Tissue Destruction in Rheumatology: Understanding Tissue Activity and Its Implications for Drug Development 

Fibrogenesis, fibroblast activity and tissue destruction and its relevance in autoimmunity, PsA, RA, SSc and lupus 

The body continuously regenerates, which inherently means that tissue is constantly being broken down and formed. In autoimmune diseases we usually focus on inflammation and immune activity, but inflammation is what starts the process, not what causes the lasting harm. The damage comes when that balance tips, fibroblasts become activated, and cartilage, bone, and connective tissue are broken down faster than the body can repair them.
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Join us to explore how evaluating tissue activity reveals what is actively happening in the disease biology, whether a treatment is truly working, and how these insights can support the development of better therapies in autoimmunity, PsA, RA, SSc and lupus. 

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Format

60-70 minutes presentation followed by 20-30 minutes of audience Q&A.

Agenda
- Introduction and welcome & Myth busting with Unicorn biomarkers | Prof. Dr. Morten Karsdal

- When inflammation isn't enough: Synovial Tissue Fibrosis as a Driver of Treatment-Refractory RA | Dr. Kevin Wei

- From tissue biology to clinical application: how fibrogenesis and tissue destruction markers are used for prognosis, pharmacodynamics and prediction in RA, PsA and SSc | Dr. Anne-Christine Bay-Jensen

- Fibrosis and inflammation of the Skin and Lung in Systemic Sclerosis: Tracking tissue remodeling, progression and treatment response with biomarkers | Prof. Dr. Shervin Assassi

- Q&A

Speakers
Dr. Kevin Wei, MD
Prof. Dr. Shervin Assassi
Dr. Anne-Christine Bay-Jensen

Expected duration
90 minutes

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