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Beautiful Collagens: Inflammatory Skin Diseases and the ECM


While collagens are commonly known as skincare and beauty products, we know that they play a central role in the ECM. Beyond the surface, the beautiful collagens of the skin play a pivotal role in the biology of diseases. You will hear about the Dermal ECM in tissue homeostasis and disease, pre-clinical models of inflammatory and fibrotic skin diseases, and learnings from drug development in psoriasis and beyond, including inflammatory skin diseases, fibroblasts, and pharmacology.

oin our ECM focused Dermatology Symposium to dive into the structure of the Dermal ECM, and how this is related to tissue homeostasis and disease. The Webinar will cover topics from preclinical development of inflammatory and fibrotic models, and lessons learned from drug development in diseases such as atopic dermatitis, hidradenitis suppurativa and psoriasis.
Connect with experts and industry leaders and get a glimpse into the future of skin research and development.
 
More specifically, we will get an introduction to how skin regenerates to maintain its tissue homeostasis, and what leads to disease. We will get a glimpse of advanced preclinical models designed to test anti-inflammatory and anti-fibrotics, and venture into a clinical setting. We will take a look at psoriatic diseases as a part of MHC class I-opathies involving manifestations in the skin, nails, synovium, joint, bone, and gut, and dive into symptoms that result from dysregulation of leukocytes, keratinocytes, fibroblasts, osteoclasts, osteoblasts, and intestinal epithelium. Among others, we will discuss the use of biomarkers using biologics or small molecules to reveal targets and pathways linked to disease manifestations. And much more!

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Agenda

11:00 – 11:10 Introductions & ECM 2024 – Dr. Morten A. Karsdal

11:10 – 11:25 The Dermal ECM in Homeostasis and Disease: An Introduction – Dr. Alexander Nyström

11:25 – 11:40 Mechanical Control of Pro-fibrotic Exosome Formation by Mesenchymal Stromal Cells – Dr. Boris Hinz

11:40 – 11:55 Learnings From Drug Development in Psoriasis and Beyond: Inflammatory Skin diseases, Fibroblasts, and Pharmacology – Dr. Peter Schafer

11:55 – 12:10 Understanding the Extracellular Matrix to Aid Personalized Medicine and Drug Development – Dr. Signe Holm Nielsen

12:10 – 12:30 Questions from the chat​​​​​​​

Expected duration
90 minutes

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