CAFs and the ECM: Structural Remodeling, Immune Effects, and Non-Invasive Measurements

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Date and time

Monday

January

16:00 CET

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CAFs and the ECM: Structural Remodeling, Immune Effects, and Non-Invasive Measurements

Join this ECM Pharmacology Symposium to explore how cancer-associated fibroblasts (CAFs) and the extracellular matrix (ECM) operate as functional units that shape tumor biology—and how these mechanisms can be translated into clinically useful readouts.

The session connects mechanistic insights from human pancreatic and breast cancer with emerging non-invasive ECM-derived biomarkers of CAF activity and immune cell dynamics.

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Format
60-70 minutes presentation followed by 20-30 minutes of audience Q&A.

Agenda and Speakers
Welcome and Introduction (Chair) | Dr. Morten Karsdal — 10 min

CAF/ECM Functional Units and Clinical Translation in Human Pancreatic Cancer | Prof. Dr. Edna Cukierman (Fox Chase Cancer Center) — 20 min

Copper Depletion, ECM/Collagen Remodeling, and Immune Response in Breast Cancer | Prof. Dr. Linda T. Vahdat (Dartmouth Hitchcock Medical Center) — 20 min

Non-Invasive ECM-Derived Biomarkers of CAF and Immune Cell Activity in Clinical Cancer Research | Dr. Nicholas Willumsen (Nordic Bioscience) — 20 min Q&A — 20 min

Expected duration
90 minutes

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